Uric Acid is produced in the body by too much artificially produced and refined fructose corn syrup. High levels of Glucose in the brain becomes sorbitol then into fructose which then produces uric acid in the brain with consequences of inflammation and oxidation stress which can then create Alzheimer's (the brain on fire), compromised and damaged enzymatic pathways and dysfunctional mitochondria that cannot produce energy the brain cells need. Apoptosis - the suicide pathway of brain cells and their loss. Uric acid leads directly to inflammation, insulin resistance and array and functionality of gut bacteria.
Uric Acid inhibits nitric oxide needed to relax blood vessels and increase blood supply.
Dehydration initiates production of high sodium which creates fructose in the body.
Uric Acid stimulates fructokinase.
Uric Acid: A KEY Cause of Weight Gain, Diabetes, Heart Disease & Dementia (Dr. David Perlmutter)
https://www.youtube.com/watch?v=QZ6jPCcFNa8
Levels Chief Medical Officer, Dr. Casey Means, chatted with our advisor, Dr. David Perlmutter on the discovery of how the elevation of uric acid in the body is a causative mechanism in the development of metabolic diseases, and one of the key links between obesity, diabetes, heart disease, neurologic diseases like dementia, ADHD, fatty liver disease, and more.
They also covered:
- The several mechanisms of how uric acid causes cellular dysfunction and insulin resistance, including oxidative stress, inflammation, and even preventing insulin from getting out of the blood stream effectively.
- The evolutionary reasons why the metabolic dysfunction and weight gain caused by uric acid would have benefitted us historically in terms of low access to food and water, by letting us more easily pack on weight and raise blood pressure. And how we now live in an evolutionary-environmental mismatch where this survival mechanism is now hurting us in the face of caloric abundance.
- The different dietary and environmental factors that generate uric acid, including fructose, purine rich foods and umami foods, dehydration, alcohol, and more.
- The optimal levels for uric acid.
- How uric acid impairs our hunger signals, drives us to eat, and even promotes risk taking behavior. We talked about how to reverse high uric acid levels as a way to unlock optimal health.
00:00 - Intro
03:12 - More than just gout
05:06 - A causative role
07:44 - The number one cause of death
15:24 - Evolutionary environmental mismatch
16:58 - High fructose corn syrup
22:27 - The dangers of uric acid
23:38 - uric acid and dementia
30:33 - Too much fructose
41:32 - Erectile dysfunction and cardiovascular risk
01:03:17 - No need to eat sugar
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Uric acid and metabolic health with Dr David Perlmutter MD
https://www.youtube.com/watch?v=UOsEoQthvMQ
When I was at medical school the subject of Uric acid levels was typically paired with gout, high purine levels in the diet and one of the most ubiquitous and successful drugs allopurinol which is used to reduce uric acid levels by inhibiting xanthine oxidase, preventing crystals that can lodge in our joints causing pain.
But there is a lot more to do with uric acid than Uricemia
Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition.
Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease and has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.
In addition, he is a frequent lecturer at symposia sponsored by institutions such as the World Bank and IMF, Columbia University, Scripps Institute, New York University, and Harvard University, and serves as an Associate Professor at the University of Miami Miller School of Medicine.
He is the editor of The Microbiome and the Brain authored by top experts in the field and published in December 2019 by CRC Press. His latest book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases, and was published in February 2022.
- A treatment for gout flare-ups is fecal microbial transplant from gout free individuals.
CHAPTERS:
Timecodes:
00:00 - Introduction
03:43 - Uric-Acid in Evolution
08:18 - The Adult in the Room
11:31 - Uric-Acid Deep Dive
16:37 - Glucose In the Brain
21:11 - Uric-Acid in The Gut
27:28 - Fructose Overload
31:35 - Modern Age Adaption
41:25 - Final Thoughts
FOR MORE INFORMATION FROM DR DAVID PERIMUTTER:
Website - https://www.drperlmutter.com
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Twitter - https://twitter.com/davidperlmutter
YouTube - https://www.youtube.com/user/DavidPer...
Instagram - https://www.instagram.com/davidperlmu...
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See Also
fructose
Fructokinase
insulin
gout
metabolic water
purine
sucrose
sugar
Uric Acid