Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.
Drug interactions
Drug interactions may occur if salicylanilides such as dibromsalan and niclosamide are co-administered. Abortions in cattle and death in sheep have been reported after using these medications together. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.[citation needed]
Toxicity
Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally. Given its low toxicity and high tolerability among different species, the possibility of repurposing it as a drug to treat cancer in humans has been proposed.
Metabolism
Fenbendazole is metabolized in the liver to oxfendazole, which is anthelmintic too; oxfendazole partially gets reduced back to fenbendazole in the liver and rumen. Also, fenbendazole itself is an active metabolite of another anthelmintic drug, febantel. wikipedia
Commentary
FENBENDAZOLE and cancer - at least 12 Anti-cancer mechanisms of action. Not approved by FDA. Cheap. Safe. Kills aggressive cancers. Why no Clinical Trials? Benzimidazole drugs (including Fenbendazole) have widely been used as anti-helminth agents in both human and/or livestock since the 1960s
Due to their low cost and high efficacy, benzimidazole anthelmintics have been used throughout the world
Ivermectin is FDA approved.
Fenbendazole is NOT approved for human use by Food and Drug Administration (FDA) and European Medicines Agency (EMA). A close relative of Fenbendazole called Mebendazole is approved by FDA and has several Clinical Trials for cancer Treatments in Brain cancer and Colon cancer. It's way more expensive!
Why no Clinical Trials currently for Fenbendazole? It's cheap! No one will get rich off Fenbendazole.
Fenbendazole has at least 12 proven anti-cancer mechanisms in vitro and in vivo:
disrupts microtubule polymerization (major mechanism)
blocks glucose transport and impairs glucose utilization by cancer cells (major)
increases p53 tumor suppressor levels! (major)
inhibits cancer cell viability, migration, invasion
What about COVID-19 mRNA Vaccine Induced Turbo cancers?
Fenbendazole shows in vitro and/or in vivo activity against these cancers:
breast cancer (including triple negative breast cancer - which is seen in COVID-19 mRNA Vaccinated individuals with Turbo cancer)
lymphomas (these are the most common COVID-19 mRNA Vaccine Turbo cancers and there is more evidence for Fenbendazole treating Lymphomas than with Ivermectin) leukemias (most aggressive COVID-19 mRNA Vaccine Turbo cancers - patients have no good treatment options)
glioblastomas and gliomas (extremely aggressive COVID-19 mRNA Vaccine Turbo cancers with poor prognosis - patients have no good treatment options)
lung cancer (NSCLC) (strong signal for COVID-19 mRNA Vaccine Turbo cancers)
hepatocellular carcinoma (signal for COVID-19 mRNA Vaccine Turbo cancers and all hepatobiliary cancers including Gallbladder and pancreas)
rhabdomyosarcomas (possible signal for COVID-19 mRNA Vaccine Turbo cancers, sarcomas in general are on the rise after mRNA vaccination and they are extremely aggressive)
ovarian cancers Although the anti-parasitic Fenbendazole is not FDA approved for human use, there is extensive evidence of anti-cancer effects in the published literature, both in vitro and in vivo
This is NOT a controversial medication, as it has been made out to be! Don't let the smears mislead you.
This is a serious anti-cancer agent!
Fenbendazole has an excellent safety profile and its close relative, Mebendazole is FDA approved, and it’s undergoing several Clinical Trials for cancer Treatments in the US right now, including colon cancers and brain cancers.
I believe that it is a reasonable hypothesis that COVID-19 mRNA Vaccine Turbo cancer patients could benefit significantly from either Mebendazole or Fenbendazole and I would love to see urgent clinical trials with both.
Fenbendazole had Clinical Trials in the past - again, not a controversial medication.
More in the article (including Joe Tippens cancer Protocol that he used for terminal Small Cell Lung cancer, other cancer protocols using Fenbendazole 444mg, etc):
The only caveat that I'd make is the dosing. 222mg and 444mg won't cut it. Fenbendazole is always dosed in animals by body weight. Cows get 5mg/kg. Canines get 50-100mg/kg. Primates get 30-50mg/kg. This is because fenbendazole is fat soluble. Longer intestines means its takes longer to travel through the digestive tract and remains active longer. Cows have 4 stomachs. Shorter intestines require a higher dose because the med will travel through the digestive tract quickly. https://t.me/RRR_GreatMindsByDesign
Something else worth noting, fenbendazole is effective against parasites that impact tissue. Ivermectin is effective against parasites that impact the blood. Taken in rotation provides a broad spectrum approach against many diseases and cancers. Well, I'd say I'm closer to being a primate than a canine, so I follow the 30-50mg/kg range. I'm usually at the upper limit of that. I'm 220lbs and take 5000mg (50mL of Safeguard liquid fenbendazole). I also rotate with other dewormers.
For reference, I'm 220lbs (100kg) and take 5,000mg (50mL of Safeguard liquid fenbendazole). So I'm at the upper limit of the 30-50mg/kg range. I add a little bit of water to dilute. I always take with a fatty meal (dinner). Others mix with chocolate milk.
WARNING: Herxheimer reactions...caused by die off.
mebendazole is also quite effective for parasites and likely as an anticancer agent as well...
vermox tablets are 500mg and generally sell for under $10
The Overlooked Miracle Drug for Cancer? Why Big Pharma Fears Fenbendazole
At least 12 anti-cancer mechanisms of action. Nine research papers reviewed.
By
Influencers
Image Source: 2020 Aug - Deok-Soo Son et al
This article originally appeared on makismd.substack.com and was republished with permission.
Guest post by Dr. William Makis
Papers and Articles Reviewed:
2023 Jun - Movahedi et al - Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
2023 Apr - Chi-Son Chang et al - Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer
2023 Mar - Semkova et al - Redox-mediated Anticancer Activity of Anti-parasitic Drug Fenbendazole in Triple-negative Breast Cancer Cells
2023 Mar - Haebeen Jung et al - Differential cytotoxic effects of fenbendazole on mouse lymphoma EL-4 cells and spleen cells
2022 Sep - Deokbae Park et al - Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
2022 Jan - Li-wen Ren et al - Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle
2020 Aug - Deok-Soo Son et al - The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs
2020 Jun - Yong Han et al - Involvement of reactive oxygen species in the anti-cancer activity of fenbendazole, a benzimidazole anthelmintic (leukemia)
2018 Aug - Dogra et al - Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
2023 Jun - Movahedi et al - Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
Benzimidazole drugs (including Fenbendazole) have widely been used as anti-helminth agents in both human and/or livestock since the 1960s
These drugs have rapidly become more popular than previous medications due to superiority in terms of efficacy, toxicity and application
Benzimidazole drugs are considered as non-toxic anti-helminth agents in humans and livestock. Acute toxicities are rarely reported for these drugs.
Neither chronic adverse effects in dogs and rats treated with very high dosages, nor irritation, carcinogenicity or teratogenicity in treated rats and rabbits have been observed
Two major mechanisms of action:
1. antimitotic activity (inhibition of tubulin polymerization by binding to tubulin sites of rapidly dividing cells (leads to cell cycle arrest)
2. disrupt cell metabolic processes by inducing oxidative stress
Result: induce apoptosis (cell death) of rapidly proliferating parasites and cancer cells!
More at the link:
https://vigilantnews.com/post/the-overlooked-miracle-drug-for-cancer-why-big-pharma-fears-fenbendazole
Fenbendazole Cancer Protocol
The Fenbendazole Cancer Protocol has been gaining rapid interest over the past year following some fenbendazole cancer success stories. The most recognized one is of a man diagnosed with stage 4 small cell Lung cancer that sent home with a 3-month life expectancy. He started taking fenbendazole (Panacur C), a dog dewormer, with some additional supplements. The following PET scan showed remarkable improvement, and after a few months, he was declared cancer-free.
Fenbendazole Protocol – A Simple Step-by-Step Guide
The basic fenbendazole protocol people follow is surprisingly simple and includes a few added supplements to the fenbendazole:
1. Fenbendazole
2. Curcumin
3. CBD Oil
4. Berberine
5. Quercetin
More here: https://healnavigator.com/treatments/fenbendazole-cancer-protocol/